hrp0086p1-p601 | Growth P1 | ESPE2016

A Lipid-Based System for the Oral Delivery of Growth Hormone

Fricker Gert , Pantze Silvia , Parmentier Johannes , Helm Frieder , Hartmann Klaus , Gropp Felix

Background: Bioavailability of peptide/protein – drugs is extremely low after oral administration due to their instability in the gastrointestinal tract or poor absorption.Objective and hypotheses: Oral delivery of growth hormone and somatostatin by adding extreme stable lipids.Method: A liposomal system based on a combination of standard lipids and membrane spanning tetraether lipids, which are extremely stable biomolecules. ...